Medical College of Wisconsin
Press Release

Medical College of Wisconsin to Study Brain Changes Following Loss of Loved One to Prevent Grief-Related Complications

Now Enrolling Participants in Landmark Brain Imaging Study

By - Aug 7th, 2020 12:52 pm

Milwaukee, Wisconsin, July 28, 2020 – Experiencing the death of a loved one is inevitable, and grief is a natural response. Most grieving adults are resilient and recover their pre-loss functioning within a year; however, about 10 percent develop intense and debilitating grief, also known as prolonged grief disorder, or complicated grief. Those individuals face detrimental medical and cognitive health outcomes and have an increased risk of suicide and premature death.

The Medical College of Wisconsin (MCW) has received a five-year, $2.6 million grant from the National Institutes of Health (NIH) National Institute of Mental Health (NIMH) to study how changes in brain activity might signal which bereaved individuals are at high risk for a complicated grief symptom trajectory and development of prolonged grief disorder. This is the first such comprehensive brain imaging study on grief and loss in the country to receive NIMH funding.

Principal investigator on the study Joseph S. Goveas, MD, associate professor in the Department of Psychiatry and Behavioral Medicine and Institute for Health and Equity and director of geriatric psychiatry at MCW, and his research team will enroll 115 participants aged 50 years and older who have experienced the loss of a loved one within the last six months. Each participant will complete multiple clinical assessments and brain scans over the course of one year, with the goal of identifying any changes in the brain that signal whether or not the individual will experience a complicated grief trajectory. A comparison group of 55 non-grieving individuals will also complete clinical assessments and brain scans.

“Despite the magnitude of this problem, we are currently not able to distinguish the biological differences between those who are resilient from those who are prone to complicated grief trajectories,” said Dr. Goveas. “Brain imaging-based markers that can characterize the clinical course during the first year for those experiencing acute grief are critically needed.”

Based on the results of a pilot study by Dr. Goveas’ team that began in 2016, the researchers believe that in adults with acute grief, features of emotion dysregulation in the brain are early and critical measures of complicated grief symptom trajectories and development of prolonged grief disorder. The pilot study looked at brain scans of grieving individuals and revealed that increased activity between the amygdala, a region of the brain that processes negative emotions, and the frontal lobe signaled a greater risk for future complications.

“The goal of this latest NIH-funded study is to validate the findings of the pilot study and identify biomarkers of prolonged grief disorder,” Dr. Goveas said. “Ultimately, we aim to use this knowledge to test treatment or prevention strategies in the most at-risk grieving individuals to prevent future complications, like prolonged grief disorder, depression, cognitive decline and suicide.”

“Dr. Goveas’ dedication to serving patients who are grieving is admirable and inspiring,” said Jon A. Lehrmann, MD, chair and Charles E. Kubly Professor in psychiatry and behavioral medicine at MCW. “In utilizing the most current and innovative research and prevention methods, Dr. Goveas’ efforts continue to enhance the health and wellbeing of many people here in our region.”

Dr. Goveas is joined by a team of MCW co-investigators, including Shi-Jiang Li, PhD, professor of biophysics and psychiatry and behavioral medicine, and Yang Wang, MD, PhD, associate professor of radiology. Other MCW personnel include Gang (Jeff) Chen, PhD, research scientist in the Department of Biophysics; B. Douglas Ward, imaging biostatistician in the Department of Biophysics, and Stacy Claesges, clinical research coordinator in the Department of Psychiatry and Behavioral Medicine.

Charles F. Reynolds III, MD, Distinguished Professor of Psychiatry and Endowed Professor in Geriatric Psychiatry emeritus at the University of Pittsburgh School of Medicine, adjunct professor of psychiatry at the Tufts School of Medicine and Maine Medical Center, and editor-in-chief of the American Journal of Geriatric Psychiatry, serves as a consultant.

Funding for the pilot study was provided by the Costigan Family Foundation.

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